ASHG 2024: Advancing Human Genetics Through Multi-Omics Innovation
November 21, 2024
The 2024 American Society of Human Genetics (ASHG) Annual Meeting, held at the Colorado Convention Center in Denver, brought together leading researchers and innovators to showcase groundbreaking advancements in genomics and spatial technologies.
This was our first time attending a conference in the snow, and as you can see, even the iconic blue bear outside the convention center was blanketed in white. But the snow didn’t slow anyone down—if anything, it seemed to add excitement to the event. Researchers braved the cold to visit booths and engage in discussions, and we were thrilled to see such a strong turnout at ours. Maybe the snow worked in our favor after all!
This year’s conference spotlighted transformative advancements in multi-omics and their applications in human genetics research.
The Complete Genomics team was excited to participate and share updates on our innovative technologies.
Key highlights include:
- DNBSEQ-G400 FluoXpert: Our newest platform enables in vivo spatial protein detection and seamless multi-omics analysis, combining DNA, RNA, and protein data into a single system.
- DNBSEQ-G800: The latest addition to our sequencing platform lineup, offering single-end reads of up to 600 bp and enabling researchers to tackle challenging genomic regions with exceptional accuracy.
- CompleteWGS Workflow: This comprehensive solution allows laboratories to sequence genomes routinely, delivering high-quality data that is both cost-effective and scalable.
- STOmics Partnership: We are thrilled to announce a new collaboration with STOmics to provide spatial transcriptomics capabilities, empowering researchers to explore tissue biology using our spatiotemporal multi-omics platform.
CoLab Talk by Dr. Joe Yeong
One of the conference highlights was our CoLab talk, presented by Dr. Joe Yeong of Singapore General Hospital. With over 100 attendees, the session explored a revolutionary approach to spatial multi-omics that integrates technologies like GoSpatial, FluoXpert, and Stereo-seq.
Dr. Yeong’s “When 1 + 1 > 2” presentation showcased how combining DNA, RNA, and protein analyses while maintaining native spatial relationships offers insights far beyond what individual technologies can achieve. By preserving spatial context, researchers can better understand complex biological systems, paving the way for molecular analysis and human genetics research breakthroughs.
Industry workshop
Our industry workshop demonstrated the power of combining multi-omics technologies to achieve comprehensive biological insights and advance precision medicine. The session highlighted how DNBSEQ-T7 sequencing integrates seamlessly with CompleteWGS and STOmics’ Stereo-seq technology to uncover intricate cellular processes.
Distinguished speakers included:
Dr. Michael Snyder (Stanford University): Presented groundbreaking discoveries using DNBSEQ™ technology to drive omics innovation.
Dr. Gang Wu (St. Jude Children’s Research Hospital): Discussed complex rearrangements in extrachromosomal DNA using linked-read sequencing.
Dr. Sky Lee (University of Colorado Anschutz): Showcased cost-effective whole-genome sequencing at $350 per human genome using the DNBSEQ-T7 platform.
These presentations highlighted how integrating genomics, spatial transcriptomics, and proteomics provides unprecedented insights into gene expression, protein dynamics, and variant detection—driving advancements in human genetics and precision medicine.
Dinner & Workshop: Exploring Spatial Omics
Spatial omics is one of the most sought-after topics in genomics, but its complexity often leaves researchers unsure where to begin. To address this, we hosted a dinner and workshop featuring two speakers who shared practical insights into leveraging Stereo-seq and DNBSEQ technologies for cutting-edge research.
Dr. Yongfu Wang (Complete Genomics): Opened the evening with a talk showcasing the capabilities of Stereo-seq and DNBSEQ for achieving single-cell resolution spatial transcriptomics across diverse biological applications.
Dr. Hui Shen (Tulane University): Presented pioneering research on creating the first subcellular resolution spatial transcriptome atlas of the human prefrontal cortex in Alzheimer’s disease.
Following the presentations, roundtable discussions sparked fascinating conversations on spatial transcriptomics’ transformative potential in drug discovery and disease research. We’re grateful to everyone who stayed late to share their passion for spatial omics.
Full Circle: Connecting Innovation with Impact
As ASHG 2024 came to a close, the energy and enthusiasm of attendees reaffirmed the enormous potential of integrated multi-omics approaches. We are incredibly grateful to everyone who visited our booth, attended our workshops, and contributed to insightful discussions about the future of genomics.
Presentations by experts like Dr. Joe Yeong, Dr. Michael Snyder, and Dr. Hui Shen underscored the transformative power of combining DNBSEQ sequencing, Stereo-seq spatial transcriptomics, and proteomics technologies. These innovations drive discoveries in precision medicine, disease research, and therapeutic development.
Looking ahead, we’re excited to continue partnering with the research community to accelerate breakthroughs in human genetics. Stay connected with us as we work together to shape the future of genomics.
See you at ASHG 2025 in Boston!
Complete Genomics Team
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